Dual responsive hybrid hydrogels for controlled release of local anesthetic

Inteligent hydrogels, such as pH sensitive hydrogels based on poly(methacrylic acid) (PMAA) are widely used for targeted drug delivery. Still, PMAA lack of good mechanical properties often limits its application. In order to overcome this limitation nanocellulose (NC) was extracted from wood waste material and then added because NC is biocompatible, non-toxic has excellent properties. Further, carboxymethyl cellulose (CMC) (cellulose derivate controlled release drugs) added. CMC can stabilize magnetite nanoparticles (MN) which also MN significantly improve possess magnetic due be The as-prepared protect drug, deliver it the site action, control rate enable in that way efficient application with reduced side effects. Local anesthetic - lidocaine hydrochloride (LH) administrated by injection induce severe This problem solved present study encapsulating LH into PMAA, NC, (PMNC/MN-L). PMNC/MN-L were characterized FTIR SEM spectroscopies single compressive tests their swelling behavior analyzed. Present offers unique approach green synthesis dual responsive improves local